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A variety of neurotransmitter pathways, as well as various peripheral feedback signals, regulate the secretion of GH by acting directly on the anterior pituitary gland and/or by regulating the release of GHRH or somatostatin in the hypothalamus ( GH receptor is a member of the class I cytokine receptor family and exists in almost all cell types in the human body (Figure 1)

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Thompson, K.S., and Liu, W.H