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CONDITIONS ASSOCIATED WITH A SUBOPTIMAL COBALAMIN STATUS Hypocobalaminemia and cobalamin deficiency can have a variety of causes in dogs including exocrine pancreatic insufficiency (EPI), chronic severe ileal disease (eg, infiltrative disorders such as idiopathic inflammatory bowel disease [IBD], alimentary lymphoma, or GI histoplasmosis), SI dysbiosis (though this condition is rarely definitively diagnosed as the acquisition and analysis of the SI microbiota is cumbersome and invasive), and inherited conditions (Fig
